protein
| function as a genetic modifier of SCN1A |
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phosphorylation of the Pro-Gly-Ser-Pro motif within L1 of SCN8A is necessary for stress-induced current modulation, with positive or negative regulation depending upon the availability of the C-terminal Pro-Ser-Tyr motif to bind NEDD4L |
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MAP1B facilitates trafficking of SCNA8 to the neuronal cell surface |
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PUM2 is able to directly bind the predominant SCN8A expressed in pyramidal neurons and, through doing so, regulates translation of this key determinant of membrane excitability |
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CALM1 is known to modulate the inactivation kinetics of SCN8A by interacting with its IQ motif |
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APP enhances SCN8A sodium channel cell surface expression through a Go-coupled JNK pathway |
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FGF14 binds directly to SCN8A C-tail, regulating channel gating and expression, properties that are required for intrinsic excitability in neurons |
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RER1 controls the assembly and transport of SCN1A, SCN8A, the principal sodium channels responsible for recurrent firing, in Purkinje cell (PC) |