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FLASH GENE
Symbol NME3 contributors: mct - updated : 27-12-2023
HGNC name non-metastatic cells 3, protein expressed in
HGNC id 7851
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a putative leucine-zipper domain
  • a Kpn (Drosophila Killer of prune) loop
  • a RGD domain
  • a C terminal extension preceded by the YEEEEP motifs
    • HOMOLOGY
    interspecies homolog to Dynamo1
    intraspecies homolog to homolog to nucleoside diphosphate kinase 3
    Homologene
    FAMILY nucleoside diphosphate kinase (NDPK) family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,outer
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,cytosolic
    text
  • endogenous NME3 localizes to the basal body and that it associates also with centrosomal proteins, such as NEK6, which regulates cell cycle arrest after DNA damage
    • basic FUNCTION
  • inhibiting granulocyte differentiation and inducing apoptosis
  • involved in the phosphorylation of nucleoside diphosphates
  • playing a role in normal hematopoiesis
  • NME1 and, more recently, NME3, have been implicated in repair of both single- and double-stranded breaks in DNA
  • separate functions of NME3 in mitochondrial fusion and NDP kinase cooperate in metabolic adaptation for cell survival in response to glucose starvation
  • contribution of NME3 to redox-regulated genome stability lies in its function in mitochondrial fusion
  • NME3 plays likely an important role in peroxisome division in a manner dependent on its NDP kinase activity
  • NME3 binds to phosphatidic acid and mediates PLD6-induced mitochondrial tethering
    • CELLULAR PROCESS cell cycle
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    nucleotide
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • NME3 as one specific NDP kinase that interacts directly with Tip60, a histone acetyltransferase, to form a complex with RNR (ribonucleotide reductase)
  • NME3 binds to several NPHPs, including NEK8, CEP164, and ankyrin repeat and sterile &
    • 945; motif domain-containing 6 (ANKS6)
  • NME3, is required for PLD6-induced mitochondrial tethering or clustering
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in chronic myelogenous leukemia (differentiation arrest and blastic transformation)
    constitutional germinal mutation      
    may aggravate the ciliopathy phenotypes observed in humans
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS