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FLASH GENE

Symbol

NME3

contributors: mct - updated : 27-12-2023

HGNC name	non-metastatic cells 3, protein expressed in
HGNC id	7851

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	1.22 kb     5 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Promoter (CAAT box)
	Binding site   transcription factor
text structure	no TATA box, two binding sites for AP-2

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_002513 5 - 848 NP_002504 - 169 - 2020 32708927

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine colon   highly Endocrine pancreas       highly Visual eye       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone     highly

cell lineage	preferentially, at early stage of myeloid differentiation, hematopoietic cells
cell lines	cell tumor lines (carcinoma of breast colon)
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a putative leucine-zipper domain
	a Kpn (Drosophila Killer of prune) loop
	a RGD domain
	a C terminal extension preceded by the YEEEEP motifs

HOMOLOGY

interspecies

homolog to Dynamo1

intraspecies

homolog to homolog to nucleoside diphosphate kinase 3

Homologene

FAMILY

nucleoside diphosphate kinase (NDPK) family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria,outer
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,cytosolic
text	endogenous NME3 localizes to the basal body and that it associates also with centrosomal proteins, such as NEK6, which regulates cell cycle arrest after DNA damage

basic FUNCTION	inhibiting granulocyte differentiation and inducing apoptosis
	involved in the phosphorylation of nucleoside diphosphates
	playing a role in normal hematopoiesis
	NME1 and, more recently, NME3, have been implicated in repair of both single- and double-stranded breaks in DNA
	separate functions of NME3 in mitochondrial fusion and NDP kinase cooperate in metabolic adaptation for cell survival in response to glucose starvation
	contribution of NME3 to redox-regulated genome stability lies in its function in mitochondrial fusion
	NME3 plays likely an important role in peroxisome division in a manner dependent on its NDP kinase activity
	NME3 binds to phosphatidic acid and mediates PLD6-induced mitochondrial tethering

CELLULAR PROCESS	cell cycle

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

nucleotide

a component

INTERACTION

DNA

RNA

small molecule

protein	NME3 as one specific NDP kinase that interacts directly with Tip60, a histone acetyltransferase, to form a complex with RNR (ribonucleotide reductase)
	NME3 binds to several NPHPs, including NEK8, CEP164, and ankyrin repeat and sterile &
	945; motif domain-containing 6 (ANKS6)
	NME3, is required for PLD6-induced mitochondrial tethering or clustering

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in chronic myelogenous leukemia (differentiation arrest and blastic transformation) constitutional germinal mutation       may aggravate the ciliopathy phenotypes observed in humans

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS