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FLASH GENE
Symbol C8B contributors: mct - updated : 11-01-2012
HGNC name complement component 8, beta polypeptide
HGNC id 1353
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal TSP1 modules of C8A and C8B form three-stranded antiparallel domains that are similar to one another and to homologous modules found in other proteins
  • a perforin domain
  • a LDL receptor class A and two thrombospondin type I
  • a EGF-like domain
  • 1 MACPF domain, that likewise can bind C8A-C8G and express C8 activity
    • conjugated GlycoP
    mono polymer heteromer , trimer
    isoforms Precursor
    HOMOLOGY
    interspecies ortholog to murine C8b
    intraspecies paralog to C8A
    Homologene
    FAMILY MAC family of proteins (membrane attack complex of complement)
    CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION
  • faciliting interaction of C8a with target membranes
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
  • the principal binding site for C9 lies within the MACPF domain of C8alpha
  • C8 contains three genetically distinct subunits (C8 alpha, C8 beta, C8 gamma) arranged as a disulfide-linked C8 alpha-gamma dimer that is noncovalently associated with C8 beta
  • this site and the binding sites for C8beta and C8gamma are distinct
  • C8 is composed of three genetically distinct subunits, C8A, C8B, and C8G
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other cell surface
    REGULATION
    inhibited by CD59
    ASSOCIATED DISORDERS
    corresponding disease(s) C8B
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS