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FLASH GENE
Symbol FEV contributors: mct/npt - updated : 21-08-2009
HGNC name FEV (ETS oncogene family)
HGNC id 18562
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron
cell lineage
cell lines Ewing sarcoma
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an ETS DNA binding domain
    • HOMOLOGY
    interspecies homolog to murine Fev (96.6pc)
    homolog to rattus Fev (96.6pc)
    Homologene
    FAMILY
  • ETS transcription factors family
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • may act as a transcription repressor
  • may play a role in serotonergic modulation of behavior
  • specifically expressed in central 5-HT neurons in the brain, with a predicted role in specification and maintenance of serotonergic neuronal phenotype (Rand 2007)
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding to purine-rich DNA sequences
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   translocation    
    with EWSR1 t(2;22) (q33;q12) in Ewing sarcoma
    tumoral       protein chimeric
    Ewing sarcoma and peripheral primitive neuroectodermal tumor
    Susceptibility to sudden infant death (SIDS)
    Variant & Polymorphism other alleles associated with SIDS risk (Rand 2007)
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    adult null mice showed heightened anxiety-like and aggressive behavior