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FLASH GENE
Symbol FEV contributors: mct/npt - updated : 21-08-2009
HGNC name FEV (ETS oncogene family)
HGNC id 18562
DNA
TYPE functioning gene
STRUCTURE 4.57 kb     3 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 1901 - 238 - Rand (2007)
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron
cell lineage
cell lines Ewing sarcoma
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an ETS DNA binding domain
    • HOMOLOGY
    interspecies homolog to murine Fev (96.6pc)
    homolog to rattus Fev (96.6pc)
    Homologene
    FAMILY
  • ETS transcription factors family
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • may act as a transcription repressor
  • may play a role in serotonergic modulation of behavior
  • specifically expressed in central 5-HT neurons in the brain, with a predicted role in specification and maintenance of serotonergic neuronal phenotype (Rand 2007)
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding to purine-rich DNA sequences
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   translocation    
    with EWSR1 t(2;22) (q33;q12) in Ewing sarcoma
    tumoral       protein chimeric
    Ewing sarcoma and peripheral primitive neuroectodermal tumor
    Susceptibility to sudden infant death (SIDS)
    Variant & Polymorphism other alleles associated with SIDS risk (Rand 2007)
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    adult null mice showed heightened anxiety-like and aggressive behavior