Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol FEV contributors: mct/npt - updated : 21-08-2009
HGNC name FEV (ETS oncogene family)
HGNC id 18562
Location 2q35      Physical location : 219.845.808 - 219.850.379
Synonym name
  • fused with EWS in complex translocation t(2;22)
  • FEV (fifth Ewing variant)
  • ETS oncogene family
  • PC12 ETS domain-containing transcription factor 1
    • Synonym symbol(s) PET-1, HSRNAFEV, PET1
    DNA
    TYPE functioning gene
    STRUCTURE 4.57 kb     3 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 1901 - 238 - Rand (2007)
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron
    cell lineage
    cell lines Ewing sarcoma
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an ETS DNA binding domain
    • HOMOLOGY
    interspecies homolog to murine Fev (96.6pc)
    homolog to rattus Fev (96.6pc)
    Homologene
    FAMILY
  • ETS transcription factors family
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • may act as a transcription repressor
  • may play a role in serotonergic modulation of behavior
  • specifically expressed in central 5-HT neurons in the brain, with a predicted role in specification and maintenance of serotonergic neuronal phenotype (Rand 2007)
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding to purine-rich DNA sequences
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   translocation    
    with EWSR1 t(2;22) (q33;q12) in Ewing sarcoma
    tumoral       protein chimeric
    Ewing sarcoma and peripheral primitive neuroectodermal tumor
    Susceptibility to sudden infant death (SIDS)
    Variant & Polymorphism other alleles associated with SIDS risk (Rand 2007)
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    adult null mice showed heightened anxiety-like and aggressive behavior