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FLASH GENE
Symbol GLRB contributors: mct - updated : 27-08-2012
HGNC name glycine receptor, beta
HGNC id 4329
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer heteromer , pentamer
HOMOLOGY
interspecies homolog to murine Glrb
intraspecies homolog to GLRA1
Homologene
FAMILY ligand gated ionic channels family
CATEGORY signaling neurotransmitter , receptor membrane
SUBCELLULAR LOCALIZATION     plasma membrane
basic FUNCTION
  • essential for synaptic localization
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds the trafficking proteins VPS35 and Neurobeachin (NBEA)
    • cell & other
    REGULATION
    Other regulation of GLRB dynamics by PKC thus contributes to the plasticity of inhibitory synapses and may be involved in maladaptive forms of synaptic plasticity
    ASSOCIATED DISORDERS
    corresponding disease(s) STHE4
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation      
    in hyperekplexia
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS