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FLASH GENE
Symbol CST6 contributors: mct/np - updated : 05-11-2007
HGNC name cystatin E/M
HGNC id 2478
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
STRUCTURE 1.00 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
regionally located clustered in a space of 900kb
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 627 16.5 149 - Rivenbark (2007)
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveliver   highly
Endocrinethyroid    
Lymphoid/Immunelymph node    
Reproductivefemale systemplacenta  highly
 female systembreast   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier/liningretinal pigment epithelium (RPE)  
cells
SystemCellPubmedSpeciesStageRna symbol
Skin/Tegumentkeratinocyte
Visualepithelial cell
cell lineage
cell lines
fluid/secretion found at high levels in saliva, tears, seminal plasma
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated GlycoP
HOMOLOGY
Homologene
FAMILY
  • cystatin superfamily
  • type 2 cystatin family
    • CATEGORY enzyme , secretory
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,lysosome
    basic FUNCTION
  • cysteine proteinase inhibitor acting as an acyl acceptor but not as an acyl donor
  • playing a role in the modulation of genes, particularly, genes that are highly relevant to breast cancer progression
  • cervical cancer suppressor gene (Veena 2008)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • inhibited by CST3 in retinal pigment epithelium
  • substrate for transglutaminases
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral        
    in metastatic mamary epithelial tumors cells
    tumoral     --low  
    in cervical cancer (promoter is silenced by hypermethylation and/or histone deacetylation) (Veena 2008)
    tumoral     --low  
    by hypermethylation in renal cell carcinoma (Morris 2010)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS