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FLASH GENE
Symbol ST8SIA4 contributors: - updated : 22-04-2006
HGNC name ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
HGNC id 10871
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
 thymus   highly
Lymphoid/Immunelymph node   highly
Nervousbrain    
Reproductivefemale systemuterus  highly
Respiratoryrespiratory tracttrachea  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoietic    
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal, pregnancy
Text highly in brain, lung, kidney, lowly in placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Siat8d
Homologene
FAMILY glycosyltransferase family 29
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,organelle,Golgi
basic FUNCTION
  • alpha-N-neuraminide-alpha-2,8-sialyltransferase (glycosylation), facilitating neurite outgrowth
  • catalyzing the polycondensation of alpha-2,8-linked sialic acid required for the synthesis of polysialic acid present on the embryonic neural cell adhesion molecule (N-CAM), necessary for plasticity of neural cells
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    down-regulation ofpolysialic acid during oligodendrocyte differentiation is a prerequisite for efficient myelination by mature oligodendrocytes
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS