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FLASH GENE
Symbol ADCY1 contributors: mct - updated : 27-09-2010
HGNC name adenylate cyclase 1 (brain)
HGNC id 232
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two guanylate cyclase domains
    • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to rattus Adcy 1 (92.4pc)
    ortholog to murine Adcy1 (92.7pc)
    Homologene
    FAMILY
  • adenylyl cyclase class-4/guanylyl cyclase family
    • CATEGORY enzyme , regulatory , signaling
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • involved in regulatory processes in the central nervous system
  • only required for the maturation of the retinal axon terminals whereas ADCY5 and ADCY8 are not needed
  • with ADCY8, are the only cyclases stimulated by calcium and calmodulin, making them uniquely poised to regulate neuronal development and neuronal processes such as learning and memory
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS nervous system
    PATHWAY
    metabolism purine/pyrimidine
    signaling signal transduction
    cAMP biosynthesis
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Mg2+ (2 ions per subunit)
    • protein
  • direct anchoring of both PRKACA and ADCY1 to TRPV1 by AKAP5 facilitates the response to inflammatory mediators and may be critical in the pathogenesis of thermal hyperalgesia
  • anchoring of not only PRKACA but also ADCY1 by AKAP5 is important for regulation of postsynaptic functions and specifically AMPA receptor activity
    • cell & other
    REGULATION
    activated by Ca(2+)/calmodulin (CaM), and having discrete neuronal functions
    inhibited by the G protein beta and gamma subunit complex
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS