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FLASH GENE

Symbol

ADCY1

contributors: mct - updated : 27-09-2010

HGNC name	adenylate cyclase 1 (brain)
HGNC id	232

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	7p13      Physical location : 45.614.124 - 45.762.712
Synonym name	ATP pyrophosphate lyase
	3',5'-cyclic AMP synthetase
	Ca(2+)/calmodulin-activated adenylyl cyclase
Synonym symbol(s)	AC1, BACF1, CYA1
EC.number	4.6.1.1

DNA

TYPE	functioning gene
STRUCTURE	148.59 kb     20 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_021116 20 - 12499 NP_066939 123.31 1119 - PMID: 19029295

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Nervous brain hindbrain cerebellum   highly   brain limbic system hippocampus   highly   brain diencephalon thalamus   highly Visual eye       predominantly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular       moderately Nervous autonomous       Nervous peripherous

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text

brain

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

two guanylate cyclase domains

conjugated

GlycoP

HOMOLOGY

interspecies	ortholog to rattus Adcy 1 (92.4pc)
	ortholog to murine Adcy1 (92.7pc)

Homologene

FAMILY

adenylyl cyclase class-4/guanylyl cyclase family

CATEGORY

enzyme , regulatory , signaling

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	involved in regulatory processes in the central nervous system
	only required for the maturation of the retinal axon terminals whereas ADCY5 and ADCY8 are not needed
	with ADCY8, are the only cyclases stimulated by calcium and calmodulin, making them uniquely poised to regulate neuronal development and neuronal processes such as learning and memory

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

nervous system

PATHWAY

metabolism

purine/pyrimidine

signaling

signal transduction

cAMP biosynthesis

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	Mg2+ (2 ions per subunit)

protein	direct anchoring of both PRKACA and ADCY1 to TRPV1 by AKAP5 facilitates the response to inflammatory mediators and may be critical in the pathogenesis of thermal hyperalgesia
	anchoring of not only PRKACA but also ADCY1 by AKAP5 is important for regulation of postsynaptic functions and specifically AMPA receptor activity

cell & other

REGULATION

activated by

Ca(2+)/calmodulin (CaM), and having discrete neuronal functions

inhibited by

the G protein beta and gamma subunit complex

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS