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Symbol MYBPC3 contributors: mlc/npt - updated : 09-11-2016
HGNC name myosin binding protein C, cardiac
HGNC id 7551
Corresponding disease
CMH4 cardiomyopathy, familial, hypertrophic 4
CMHNE cardiomyopathy, familial, hypertrophic, neonatal
Location 11p11.2      Physical location : 47.352.957 - 47.374.253
Synonym name
  • cardiac MyBP-C
  • cardiomyopathy, hypertrophic 4
  • protein C, cardiac
  • Synonym symbol(s) FHC, MYPC, MYBP-C, DKFZp779E1762, MYBPC, cMyBP-C
    TYPE functioning gene
    STRUCTURE 21.30 kb     35 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    MDK 11p11.2 midkine (neurite growth-promoting factor 2) CHRM4 11p12-p11.2 cholinergic receptor, muscarinic 4 LOC387765 11 LOC387765 FLJ20294 11p11.2 hypothetical protein FLJ20294 FLJ32675 11p11.2 hypothetical protein FLJ32675 KIAA0652 11p12-q11 hypothetical protein FLJ32675 ARHGAP1 11p12-q12 Rho GTPase activating protein 1 ZNF408 11p11.2 zinc finger protein 408 F2 11p11-q12 coagulation factor II (thrombin) ch-TOG 11p11.2 KIAA0097 gene product LRP4 11p12-p11.2 low density lipoprotein receptor-related protein 4 MGC4707 11p11.2 hypothetical protein MGC4707 ZNF289 11p11.2-p11.12 zinc finger protein 289, ID1 regulated PACSIN3 11p12-p11.2 protein kinase C and casein kinase substrate in neurons 3 DDB2 11p12-p11.2 damage-specific DNA binding protein 2, 48kDa ACP2 11p11.2 acid phosphatase 2, lysosomal NR1H3 11p11.2 nuclear receptor subfamily 1, group H, member 3 MADD 11p11.22-p11.21 MAP-kinase activating death domain MYBPC3 11p11.2 myosin binding protein C, cardiac SPI1 11p12 spleen focus forming virus (SFFV) proviral integration oncogene spi1 SLC39A13 11p11.2 solute carrier family 39 (zinc transporter), member 13 PSMC3 11p13-p12 proteasome (prosome, macropain) 26S subunit, ATPase, 3 RAPSN 11p11.2-p11.1 receptor-associated protein of the synapse, 43kD CUGBP1 11p11 CUG triplet repeat, RNA binding protein 1 KBTBD4 11p11.2 kelch repeat and BTB (POZ) domain containing 4 NDUFS3 11p11.11 NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase) C1QTNF4 11q11 C1q and tumor necrosis factor related protein 4 MTCH2 11p11.2 mitochondrial carrier homolog 2 (C. elegans) FLJ23598 11p11.2 hypothetical protein FLJ23598 FNBP4 11q12.1 formin binding protein 4 NUP160 11q12.1 nucleoporin 160kDa PTPRJ 11p11.2 protein tyrosine phosphatase, receptor type, J LOC119765 11p11.12 similar to Olfactory receptor 4B1 (OST208) LOC390112 11 similar to Olfactory receptor 4B1 (OST208) LOC119764 11p11.12 similar to Olfactory receptor 4X2 LOC390113 11 similar to Olfactory receptor 4X1
    TRANSCRIPTS type messenger
    text with two isoforms cardiac and fast skeletal muscle
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    35 - 4217 150 1274 - 2011 21257752
    Type restricted
       expressed in (based on citations)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheartventricle    Homo sapiens
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal   Homo sapiensFetal
    Muscularstriatumcardiac   Homo sapiens
    cell lineage
    cell lines
    at STAGE
    physiological period pregnancy
    Text placenta
  • four N-terminal regulatory domains, C0-C1-m-C2 (C0C2), influencing actin and myosin interactions, the basic contractile proteins of muscle
  • a cardiac-specific Ig-like domain C0, interacting with the regulatory light chain of myosin, thus placing the N terminus of the protein in proximity to the motor domain of myosin
  • C0 and C1 domain can each bind to the same two distinctly different positions on F-actin
  • seven immunoglobulin Ig C2 domains
  • third immunoglobulin domain of the cardiac isoform (cC2), having the beta-sandwich structure expected from a member of the immunoglobulin fold, and so-called "motif," located between the second and third immunoglobulin modules of the cardiac isoform, that is required for its Ca2+-dependent interaction with calmodulin
  • a M-domain, the major regulatory subunit of cardiac myosin-binding protein-C (MYBPC3) that modulates actin and myosin interactions to influence muscle contraction
  • three fibronectin, type III domains
  • two myosin binding sites, one close to the N terminus and the other at the C terminus
  • C terminal region binds to myosin rods and stabilizes thick filament structure
  • immunoglobulin family
  • MYBP subfamily
  • CATEGORY motor/contractile , structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    text sarcomeric protein in the A band of sarcomeres (the cross-bridge-bearing zone (C region) of A bands in striated muscle)
    basic FUNCTION
  • acting as a cross-bridge between myosin and titin, mediating adrenergic stimulation of cardiac contraction
  • accessory protein of striated muscle sarcomeres that is vital for maintaining regular heart function
  • multidomain protein present in the thick filaments of striated muscles and is involved in both sarcomere formation and contraction regulation
  • critical nodal point that has both important structural and signaling roles and whose modifications are known to cause significant human cardiac disease
  • myofibrillar protein important for normal myocardial contractility and stability
  • functions likely as a physiological brake on contraction by positioning myosin heads away from the thin filament, a constraint which is removed upon adrenergic stimulation or MYBPC3 ablation
  • multi-domain (C0-C10) protein that regulates heart muscle contraction through interaction with myosin, actin and other sarcomeric protein
  • is dispensable for the development of skeletal muscle with no functional or structural consequences in the adult myocyte, and skeletal isoforms can transcomplement in the heart in the absence of MYBPC3
  • activates thin filaments and inhibits thick filaments in heart muscle cells
  • thick filament-associated protein that seems to contribute to the regulation of cardiac contraction through interactions with either myosin or actin or both
  • regulates the rate and force of contraction in mammalian myocardium
  • signaling node in cardiac myocytes that contributes to the maintenance of sarcomeric structure and regulation of contraction and relaxation
    a component
  • component of the thick filament that appears to tune these mechanochemical interactions by its N-terminal domains transiently interacting with actin and/or the myosin S2 domain, sensitizing thin filaments to calcium and governing maximal sliding velocity
    small molecule
  • binding to beta myosin S2
  • binding to titin
  • interacts with actin via a single, moderate affinity site localized to the C-terminal region of the protein
  • CALM1 may act as a structural conduit that links MYBPC3 with Ca(2+) signaling pathways to help coordinate phosphorylation events and synchronize the multiple interactions between MYBPC3, myosin, and actin during the heart muscle contraction
  • cell & other
    Other competency for phosphorylation at multiple sites in MYBPC3 is a prerequisite for normal beta-adrenergic responsiveness
    corresponding disease(s) CMH4 , CMHNE
    related resource FHC Mutation Database
  • to chronic risk of heart failure
  • to idiopathic dilated cardiomyopathy
  • Variant & Polymorphism insertion/deletion , other
  • 25-bp deletion, a common MYBPC3 variant in South Asians, is associated with chronic risk of heart failure (Dhandapany 2009)
  • mutated in idiopathic dilated cardiomyopathy (Moller 2009)
  • Candidate gene
    Therapy target
  • elevated oxidative stress in MYPBC3-mutated dilated cardiomyopathy (DCM) mice, which may exacerbate the development of heart failure
  • mechanism leading to cardiac dilation in homozygous Mybpc3(-/-) mice is primarily myocyte hyperplasia, and mechanism leading to hypertrophic cardiomyopathy in heterozygous Mybpc3(+/-) individuals is myocyte hypertrophy (increased cell size)