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FLASH GENE
Symbol ERF contributors: mct - updated : 08-02-2018
HGNC name Ets2 repressor factor
HGNC id 3444
Location 19q13.1      Physical location : 42.751.717 - 42.759.309
Synonym symbol(s) PE-2
DNA
TYPE anonymous DNA segment
STRUCTURE 7.00 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinethyroid   highly
Nervousnerve   highly
Reproductivefemale systemovary   
 male systemtestis  highly
Visualeye   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a repression domain at the C terminus ETS DNA-binding domain
  • HOMOLOGY
    Homologene
    FAMILY ETS family
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text continuously shuttles between the nucleus and the cytoplasm and that both phosphorylation and dephosphorylation of ERF occur within the nucleus
    basic FUNCTION
  • putatively involved in carcinogenesis
  • potent transcriptional repressor that binds to the H1 element of the ETS2 promoter, and may regulate other genes
  • involved in cellular proliferation
  • mediates repression of the human cytomegalovirus major immediate-early promoter in undifferentiated non-permissive cells
  • effector of the receptor tyrosine kinase/Ras/Erk pathway
  • may be important in the control of cellular proliferation during the G0/G1 transition and that it may be one of the effectors in the mammalian Ras signaling pathway
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • suppression of FGF2 by ETS2 repressor factor (ERF) is required for chorionic trophoblast differentiation
  • cell & other
    REGULATION
    Other regulated by MAPK phosphorylation during cell cycle and mitogenic stimulation
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS