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FLASH GENE
Symbol CLEC3B contributors: - updated : 27-04-2006
HGNC name C-type lectin domain family 3, member B
HGNC id 11891
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Visualeyeanterior segmentcornea  
cell lineage
cell lines
fluid/secretion serum
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal alpha helical domain required for homo trimerization
  • six cysteine residues
  • a C terminal globular carbohydrate recognition domain, binding the kringle-4 domain of plasminogen
    • HOMOLOGY
    intraspecies homolog to asialoglycoprotein receptors and cartilage core protein
    Homologene
    FAMILY C-type lectin family
    CATEGORY adhesion
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • plasminogen binding protein
  • muscle regeneration and muscle cell differentiation in vitro
  • involved in the mineralization phase of osteogenesis and in myogenesis during embryonic development
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral        
    prognostic marker of cancers (breast, ovarian,? others)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS