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FLASH GENE
Symbol CLEC3B contributors: - updated : 27-04-2006
HGNC name C-type lectin domain family 3, member B
HGNC id 11891
DNA
TYPE functioning gene
STRUCTURE 9.00 kb     3 Exon(s)
MAPPING cloned Y linked N status provisional
Map pter - VIPR1 - D3S3112 - CLEC3B - D3S2978 - cen
Authors Durkin (97)
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Visualeyeanterior segmentcornea  
cell lineage
cell lines
fluid/secretion serum
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal alpha helical domain required for homo trimerization
  • six cysteine residues
  • a C terminal globular carbohydrate recognition domain, binding the kringle-4 domain of plasminogen
    • HOMOLOGY
    intraspecies homolog to asialoglycoprotein receptors and cartilage core protein
    Homologene
    FAMILY C-type lectin family
    CATEGORY adhesion
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • plasminogen binding protein
  • muscle regeneration and muscle cell differentiation in vitro
  • involved in the mineralization phase of osteogenesis and in myogenesis during embryonic development
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral        
    prognostic marker of cancers (breast, ovarian,? others)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS