Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol LRP8 contributors: mct/ - updated : 07-03-2017
HGNC name low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
HGNC id 6700
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a ligand-binding domain consisting of cysteine-rich repeats
  • an EGF-like homology domain
  • an 0-linked sugar domain
  • eight LDL receptor class a domains
  • 6 LDL-receptor class b domains
  • three EGF-like domains
  • a transmembrane segment
  • a cytoplasmic short tail with a NPY internalization domain
    • HOMOLOGY
    intraspecies homolog to low density lipoprotein receptor 8 (LDLR)
    homolog to LDLR, VLDLR, highly
    Homologene
    FAMILY
  • LDLR family
    • CATEGORY receptor
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    basic FUNCTION
  • inducing tyrosine phosphorylation of DAB1 and modulation of tau phosphorylation
  • possible signaling role for LRP8 in sperm development and function that is independent of selenium uptake (
  • LRP8, and LRP2 mediate tissue-specific SEPP1 uptake
  • plays important roles in structure and function of CNS synapses and dendritic spines, and these roles are modulated by cytoplasmic adaptor proteins APBA1 and DLG4
  • is essential to protect the root surface from resorption
  • pivotal role in the establishment and maintenance of normal retinal synaptic connectivity
  • positive regulator of Wnt/CTNNB1 signaling
  • novel positive factor of canonical Wnt signaling pathway and involved in Wnt-induced osteoblast differentiation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • reelin
  • proteolytic cleavage of RELN and alternative splicing of LRP8 may be involved in the fine regulation of RLN signaling
  • platelet receptor for FXI
  • RELN and apolipoprotein E (apoE), ligands of LRP8, are involved in retinal development and degeneration, respectively
  • is being the main receptor responsible for RELN mediated detachment of neuroblasts and correct migration of early generated interneurons within the olfactory bulb (OB), a prerequisite for correct OB lamination
  • HIC1 is a direct transcriptional repressor of LRP8 and VLDLR
  • CLU binds to apolipoprotein E receptor 2 (LRP8) and very low density lipoprotein receptor (VLDLR) and is internalized by cells expressing either one of these receptors
  • RELN governs cell migration through activation of multiple intracellular signaling events by means of the receptors LRP8 and VLDLR, and the intracellular adaptor protein Disabled-1 (DAB1)
  • SFRS11 directly binds to the 3' UTR of LRP8 mRNA, as well as to the third exon of APOE mRNA, resulting in stabilization of these mRNAs, eventually deactivating JNK signaling
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to fetal growth restriction
  • to premature coronary artery disease, and/or myocardial infarction
    • Variant & Polymorphism SNP , other
  • associated with fetal growth restriction
  • variants contributing to the development of premature and familial coronary artery disease, and/or myocardial infarction
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS