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FLASH GENE
Symbol FGF13 contributors: mct - updated : 27-10-2018
HGNC name fibroblast growth factor 13
HGNC id 3670
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • role of the FGF13 N-terminus in SCNA5 channel modulation
  • clusters of basic residues potentially acting as nuclear localization signals (NLS)
    • HOMOLOGY
    intraspecies homolog to fibroblast growth factor 13
    Homologene
    FAMILY
  • heparin-binding growth factors family
  • FGF11 subfamily
  • FGF homologous factor (FHF) subfamily
    • CATEGORY signaling growth factor
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule
    intracellular,nucleus,nucleolus
    text
  • enriched in axonal growth cones and interacts directly with microtubules
    • basic FUNCTION
  • may be involved in nervous system development and function
  • acts intracellularly as a microtubule-stabilizing protein required for axon and leading process development and neuronal migration in the cerebral cortex
  • essential role of FGF13 in establishing neural circuits in the cerebral cortex and enabling cognitive functions
  • not only binds to tubulins but also polymerizes and stabilizes MTs, and is likely required for the assembly of MTs in neurons
  • is required for the formation and structural refinement of axons
  • FGF13 expression is critical for hippocampal development
  • FGF11, FGF12, FGF13, FGF14 are intracellular proteins that bind and modulate voltage-gated sodium channels
  • possible role for FGF13 in hair follicle growth and in the hair cycle
  • FGF11, FGF12, FGF13, FGF14 not only are potent modulators of voltage-gated Na+ channels but also affect Ca2+ channels and their function
  • powerful role of FGF13 in control of neuronal excitability
  • is a microtubule-stabilizing protein that regulates neuronal polarization and migration
  • concerted actions of FGF13 and FGF14 regulate the polarized localization of voltage-gated sodium channels (VGSCs) that supports efficient action potential initiation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • beyond the thermosensors, the FGF13c/SCN9A omplex is essential for sustaining the transmission of noxious heat signals
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • FGF13 regulates proliferation and differentiation of skeletal muscle by down-regulating SPRY1
  • FGF13 interacted with the sodium channel SCN9A in a heat-facilitated manner (FGF13 increased SCN9A sodium currents and maintained the membrane localization of SCN9A during noxious heat stimulation, enabling the sustained firing of action potentials)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) EIEE92
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional   deletion    
    deletion encompassed only one gene, FGF13, in Wildervanck Syndrome
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • deletion of Fgf13 in mice results in neuronal migration defects in both the neocortex and the hippocampus, and Fgf13-deficient mice also exhibit weakened learning and memory