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FLASH GENE

Symbol

FGF13

contributors: mct - updated : 27-10-2018

HGNC name	fibroblast growth factor 13
HGNC id	3670

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001139500 7 - 2340 NP_001132972 - 255 - 2017 28162808 FGF13 IA NM_004114 5 - 2705 NP_004105 - 245 - 2017 28162808 FGF13A, FHF2A contains a nuclear localization signal (NLS) critical role of the FHF2A isoform in regulating Nav channel function NM_033642 5 - 1968 NP_378668 - 192 high levels of FGF13B mRNA and protein were transiently present in the neocortex and hippocampus 2017 28162808 FGF13B cytoplasmic FGF13B without an NLS NM_001139502 6 - 2093 NP_001132974 - 226 - 2017 28162808 NM_001139501 8 - 2450 NP_001132973 - 226 - 2017 28162808 NM_001139498 6 - 2172 NP_001132970 - 199 - 2017 28162808

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Homo sapiens Fetal Nervous brain forebrain cerebral cortex     Homo sapiens Fetal   brain         Homo sapiens Adult Reproductive female system ovary       Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal     Homo sapiens Muscular striatum cardiac myocardium   Homo sapiens Fetal

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron Homo sapiens Fetal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	role of the FGF13 N-terminus in SCNA5 channel modulation
	clusters of basic residues potentially acting as nuclear localization signals (NLS)

HOMOLOGY

intraspecies

homolog to fibroblast growth factor 13

Homologene

FAMILY	heparin-binding growth factors family
	FGF11 subfamily
	FGF homologous factor (FHF) subfamily

CATEGORY

signaling growth factor

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane
	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,cytoplasm,cytoskeleton,microtubule
	intracellular,nucleus,nucleolus
text	enriched in axonal growth cones and interacts directly with microtubules

basic FUNCTION	may be involved in nervous system development and function
	acts intracellularly as a microtubule-stabilizing protein required for axon and leading process development and neuronal migration in the cerebral cortex
	essential role of FGF13 in establishing neural circuits in the cerebral cortex and enabling cognitive functions
	not only binds to tubulins but also polymerizes and stabilizes MTs, and is likely required for the assembly of MTs in neurons
	is required for the formation and structural refinement of axons
	FGF13 expression is critical for hippocampal development
	FGF11, FGF12, FGF13, FGF14 are intracellular proteins that bind and modulate voltage-gated sodium channels
	possible role for FGF13 in hair follicle growth and in the hair cycle
	FGF11, FGF12, FGF13, FGF14 not only are potent modulators of voltage-gated Na+ channels but also affect Ca2+ channels and their function
	powerful role of FGF13 in control of neuronal excitability
	is a microtubule-stabilizing protein that regulates neuronal polarization and migration
	concerted actions of FGF13 and FGF14 regulate the polarized localization of voltage-gated sodium channels (VGSCs) that supports efficient action potential initiation

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

beyond the thermosensors, the FGF13c/SCN9A omplex is essential for sustaining the transmission of noxious heat signals

INTERACTION

DNA

RNA

small molecule

protein	FGF13 regulates proliferation and differentiation of skeletal muscle by down-regulating SPRY1
	FGF13 interacted with the sodium channel SCN9A in a heat-facilitated manner (FGF13 increased SCN9A sodium currents and maintained the membrane localization of SCN9A during noxious heat stimulation, enabling the sustained firing of action potentials)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

EIEE92

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional   deletion     deletion encompassed only one gene, FGF13, in Wildervanck Syndrome

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

deletion of Fgf13 in mice results in neuronal migration defects in both the neocortex and the hippocampus, and Fgf13-deficient mice also exhibit weakened learning and memory