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FLASH GENE
Symbol FGF11 contributors: mct - updated : 08-12-2021
HGNC name fibroblast growth factor 11
HGNC id 3667
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain   specific
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text eye
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
clusters of basic residues potentially acting as nuclear localization signals (NLS)
HOMOLOGY
intraspecies homolog to fibroblast growth factor 11
Homologene
FAMILY
  • heparin-binding growth factors family
  • intracellular fibroblast growth factor superfamily
  • CATEGORY signaling growth factor
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • probably involved in nervous system development and function
  • FGF11, FGF12, FGF13, FGF14 are intracellular proteins that bind and modulate voltage-gated sodium channels
  • FGF11, FGF12, FGF13, FGF14 not only are potent modulators of voltage-gated Na+ channels but also affect Ca2+ channels and their function
  • POSTN, PPP1R1A, FGF11 are potential novel mediators of adipogenesis
  • FGF11 may be involved in the stabilization of capillary-like tube structures associated with angiogenesis and may act as a modulator of hypoxia-induced pathological processes such as tumorigenesis
  • is likely a novel factor driving pathological bone resorption in osteolytic disease
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • FGF11 increased HIF1A stability by acting upstream of proteasomal degradation
  • likely FGF11 indirectly controls the expression of PPARG through modifying the expression of multiple PPARG regulators, thereby mediating adipogenesis
  • cell & other
    REGULATION
    induced by hypoxia
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    stimulated capillary-like tube formation, yet did not affect cell migration
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    osteoarticularboneostéoporosis
    potential target for the development of new anti-resorptive therapeutic agents
    ANIMAL & CELL MODELS