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FLASH GENE
Symbol FGF11 contributors: mct - updated : 08-12-2021
HGNC name fibroblast growth factor 11
HGNC id 3667
Location 17p13.1      Physical location : 7.342.688 - 7.348.249
Synonym name
  • fibroblast growth factor homologous factor 3
  • Synonym symbol(s) FHF3, FGF-11, FHF-3, FLJ16061, MGC45269, MGC102953
    DNA
    TYPE functioning gene
    STRUCTURE 6.64 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    Binding site
    text structure
  • promoter contains hypoxia response elements (HREs), and hypoxia-inducible factor-1 (HIF1) binds to HREs to activate hypoxia-related genes
  • MAPPING cloned Y linked   status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 2578 - 225 - -
    5 - 2345 - 166 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   specific
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text eye
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    clusters of basic residues potentially acting as nuclear localization signals (NLS)
    HOMOLOGY
    intraspecies homolog to fibroblast growth factor 11
    Homologene
    FAMILY
  • heparin-binding growth factors family
  • intracellular fibroblast growth factor superfamily
  • CATEGORY signaling growth factor
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • probably involved in nervous system development and function
  • FGF11, FGF12, FGF13, FGF14 are intracellular proteins that bind and modulate voltage-gated sodium channels
  • FGF11, FGF12, FGF13, FGF14 not only are potent modulators of voltage-gated Na+ channels but also affect Ca2+ channels and their function
  • POSTN, PPP1R1A, FGF11 are potential novel mediators of adipogenesis
  • FGF11 may be involved in the stabilization of capillary-like tube structures associated with angiogenesis and may act as a modulator of hypoxia-induced pathological processes such as tumorigenesis
  • is likely a novel factor driving pathological bone resorption in osteolytic disease
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • FGF11 increased HIF1A stability by acting upstream of proteasomal degradation
  • likely FGF11 indirectly controls the expression of PPARG through modifying the expression of multiple PPARG regulators, thereby mediating adipogenesis
  • cell & other
    REGULATION
    induced by hypoxia
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    stimulated capillary-like tube formation, yet did not affect cell migration
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    osteoarticularboneostéoporosis
    potential target for the development of new anti-resorptive therapeutic agents
    ANIMAL & CELL MODELS