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FLASH GENE

Symbol

FGF11

contributors: mct - updated : 08-12-2021

HGNC name	fibroblast growth factor 11
HGNC id	3667

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	17p13.1      Physical location : 7.342.688 - 7.348.249
Synonym name	fibroblast growth factor homologous factor 3
Synonym symbol(s)	FHF3, FGF-11, FHF-3, FLJ16061, MGC45269, MGC102953

DNA

TYPE	functioning gene
STRUCTURE	6.64 kb     5 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Promoter
	Binding site
text structure	promoter contains hypoxia response elements (HREs), and hypoxia-inducible factor-1 (HIF1) binds to HREs to activate hypoxia-related genes

MAPPING

cloned

Y

linked

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_004112 5 - 2578 NP_004103 - 225 - - NM_001303460 5 - 2345 NP_001290389 - 166 - -

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain       specific

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text

eye

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

clusters of basic residues potentially acting as nuclear localization signals (NLS)

HOMOLOGY

intraspecies

homolog to fibroblast growth factor 11

Homologene

FAMILY	heparin-binding growth factors family
	intracellular fibroblast growth factor superfamily

CATEGORY

signaling growth factor

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,cytoplasm
	intracellular,nucleus

basic FUNCTION	probably involved in nervous system development and function
	FGF11, FGF12, FGF13, FGF14 are intracellular proteins that bind and modulate voltage-gated sodium channels
	FGF11, FGF12, FGF13, FGF14 not only are potent modulators of voltage-gated Na+ channels but also affect Ca2+ channels and their function
	POSTN, PPP1R1A, FGF11 are potential novel mediators of adipogenesis
	FGF11 may be involved in the stabilization of capillary-like tube structures associated with angiogenesis and may act as a modulator of hypoxia-induced pathological processes such as tumorigenesis
	is likely a novel factor driving pathological bone resorption in osteolytic disease

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	FGF11 increased HIF1A stability by acting upstream of proteasomal degradation
	likely FGF11 indirectly controls the expression of PPARG through modifying the expression of multiple PPARG regulators, thereby mediating adipogenesis

cell & other

REGULATION

induced by

hypoxia

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   stimulated capillary-like tube formation, yet did not affect cell migration

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed osteoarticular bone ostéoporosis potential target for the development of new anti-resorptive therapeutic agents

ANIMAL & CELL MODELS