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FLASH GENE
Symbol PEX7 contributors: mct - updated : 08-06-2015
HGNC name peroxisomal biogenesis factor 7
HGNC id 8860
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen    
Digestiveintestinelarge intestinecolon  
Nervousbrain    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Lymphoid    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N terminal sequence with no known structural motifs
  • six consensus WD40 repeats
    • HOMOLOGY
    interspecies homolog to yeast Pts2 receptor
    Homologene
    FAMILY
    CATEGORY receptor , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,peroxisome
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • peroxisomal PTS2 receptor (peroxisome targeting signal 2), but unable to restore PTS2 protein import into peroxisomes in DP fibroblasts
  • involved in peroxisomal import of proteins containing an N-terminal peroxisome-targeting signal (PTS2)
  • cytosolic receptor that imports peroxisomal targeting signal type 2 (PTS2)-containing proteins
    • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text peroxisome
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PEX5
  • cytosolic receptor for peroxisome targeting signal 2 of peroxisomal matrix enzymes that are targeted to and translocated into the peroxisome
  • interaction strength between cargo and PEX7 is drastically increased in the presence of the co-receptor PEX5L
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) RCDP1 , PBD7
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS