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FLASH GENE

Symbol

HNRNPA1

contributors: mct/ - updated : 06-05-2017

HGNC name	heterogeneous nuclear ribonucleoprotein A1
HGNC id	5031

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	RNP (RRM), and RGG motifs
	a M9 sequence functioning as a potent nuclear localization signal different from the basic NLS, and as a nuclear export signal

conjugated

RiboP

HOMOLOGY

Homologene

FAMILY

HNRP family

CATEGORY

RNA associated

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus,nucleoplasm
text	cytoplasmic redistribution is a regulated process during viral infection and cellular stress
	nucleocytoplasmic shuttling protein with roles in many aspects of mRNA metabolism

basic FUNCTION	packaging of premRNA into HnRNP particles and transport of polyA+ mRNA from nucleus to cytoplasm
	HNRNPA1 preferentially binds TNPO1, TNPO2
	may play a possible role in the mechanism of KRAS transcription
	nucleocytoplasmic shuttling protein that regulates gene expression through its action on mRNA metabolism and translation
	having a role as auxiliary factor that facilitate the processing of specific miRNAs
	with HNRNPA2B1, and PTBP1, have critical role in promoting PKM2 production in tumours, and overexpression of some combination of them is, like PKM2 expression, likely to be a general phenomenon in cancer
	with KHSRP have antagonistic roles in the post-transcriptional regulation of MIRLET7A1, MIRLET7A2, MIRLET7A3 expression
	general RNA-binding protein having an inhibitory role in the RNASEN-mediated processing of MIRLET7As in cells that lack LIN28A, LIN28B expression
	HNRNPA1, DMRT2 and POT1 act in concert to displace RPA1 from telomeric single-stranded DNA after DNA replication, and promote telomere capping to preserve genomic integrity
	single-stranded oligonucleotide binding protein, that is thought to play a pivotal role in telomere maintenance

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	component of heterogeneous nuclear RNA ribonucleoprotein complex
	associated to premRNA in the nucleus

INTERACTION

DNA	binding to simple strand DNA

RNA

binding

small molecule

protein	binding to KPNB2 mediating the nuclear import of HNRPA1
	HNRNPA1 recruitment to stress granules involves MKNK1/MKNK2-dependent phosphorylation of mRNA-bound HNRNPA1
	binds specifically to the primary RNA sequence pri-miR-18a before Drosha (RNASEN) processing
	negative regulator of MIRLET7A1, MIRLET7A2, MIRLET7A3
	interacting with SMN2 (HNRNPA1 can inhibit splicing of SMN2 exon 7 by direct binding to the 3prime ss sequence)
	HNRNPA1 and HNRNPF modulate the alternative splicing of exon 11 of the insulin receptor gene
	MKNK1 regulates the phosphorylation and the subcellular distribution of HNRNPA1
	HNRNPA1 regulates HMGCR alternative splicing and modulates cellular cholesterol metabolism
	HNRNPA1 is one of the novel interacting partners of PSMD9 and HNRNPA1 may act as a shuttle receptor and PSMD9 as a subunit acceptor
	O-GlcNAcylation, regulates likely HNRNPA1 translocation and interaction with TNPO1, possibly affecting its function

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in gastric cancer constitutional     --over   lowering the level of secreted Abeta APP and may have a role in treating Alzheimer's disease

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS