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FLASH GENE
Symbol HNRNPA1 contributors: mct/ - updated : 06-05-2017
HGNC name heterogeneous nuclear ribonucleoprotein A1
HGNC id 5031
Location 12q13.13      Physical location : 54.674.487 - 54.679.028
Synonym name
  • core protein A1
  • helix-destabilizing protein
  • single-strand RNA-binding protein
  • nuclear ribonucleoprotein particle A1 protein
  • heterogeneous nuclear ribonucleoprotein B2 protein
    • Synonym symbol(s) UP1, HNRPA1, MGC102835
    DNA
    TYPE functioning gene
    STRUCTURE 4.54 kb     11 Exon(s)
    regulatory sequence Binding site
    text structure different sets of binding sites control splice site selection
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 1785 33.3 320 - 2009 19282454
    lacking 156 bp in the coding region, same ORF
    11 - 19241 38.7 372 - 2009 19282454
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularsmooth   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text myometrium (parturition)
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • RNP (RRM), and RGG motifs
  • a M9 sequence functioning as a potent nuclear localization signal different from the basic NLS, and as a nuclear export signal
    • conjugated RiboP
    HOMOLOGY
    Homologene
    FAMILY
  • HNRP family
    • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    text
  • cytoplasmic redistribution is a regulated process during viral infection and cellular stress
  • nucleocytoplasmic shuttling protein with roles in many aspects of mRNA metabolism
    • basic FUNCTION
  • packaging of premRNA into HnRNP particles and transport of polyA+ mRNA from nucleus to cytoplasm
  • HNRNPA1 preferentially binds TNPO1, TNPO2
  • may play a possible role in the mechanism of KRAS transcription
  • nucleocytoplasmic shuttling protein that regulates gene expression through its action on mRNA metabolism and translation
  • having a role as auxiliary factor that facilitate the processing of specific miRNAs
  • with HNRNPA2B1, and PTBP1, have critical role in promoting PKM2 production in tumours, and overexpression of some combination of them is, like PKM2 expression, likely to be a general phenomenon in cancer
  • with KHSRP have antagonistic roles in the post-transcriptional regulation of MIRLET7A1, MIRLET7A2, MIRLET7A3 expression
  • general RNA-binding protein having an inhibitory role in the RNASEN-mediated processing of MIRLET7As in cells that lack LIN28A, LIN28B expression
  • HNRNPA1, DMRT2 and POT1 act in concert to displace RPA1 from telomeric single-stranded DNA after DNA replication, and promote telomere capping to preserve genomic integrity
  • single-stranded oligonucleotide binding protein, that is thought to play a pivotal role in telomere maintenance
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of heterogeneous nuclear RNA ribonucleoprotein complex
  • associated to premRNA in the nucleus
    • INTERACTION
    DNA binding to simple strand DNA
    RNA binding
    small molecule
    protein
  • binding to KPNB2 mediating the nuclear import of HNRPA1
  • HNRNPA1 recruitment to stress granules involves MKNK1/MKNK2-dependent phosphorylation of mRNA-bound HNRNPA1
  • binds specifically to the primary RNA sequence pri-miR-18a before Drosha (RNASEN) processing
  • negative regulator of MIRLET7A1, MIRLET7A2, MIRLET7A3
  • interacting with SMN2 (HNRNPA1 can inhibit splicing of SMN2 exon 7 by direct binding to the 3prime ss sequence)
  • HNRNPA1 and HNRNPF modulate the alternative splicing of exon 11 of the insulin receptor gene
  • MKNK1 regulates the phosphorylation and the subcellular distribution of HNRNPA1
  • HNRNPA1 regulates HMGCR alternative splicing and modulates cellular cholesterol metabolism
  • HNRNPA1 is one of the novel interacting partners of PSMD9 and HNRNPA1 may act as a shuttle receptor and PSMD9 as a subunit acceptor
  • O-GlcNAcylation, regulates likely HNRNPA1 translocation and interaction with TNPO1, possibly affecting its function
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in gastric cancer
    constitutional     --over  
    lowering the level of secreted Abeta APP and may have a role in treating Alzheimer's disease
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS