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FLASH GENE

Symbol

NRGN

contributors: mct - updated : 10-03-2020

HGNC name	neurogranin (protein kinase C substrate, RC3)
HGNC id	8000

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   in patients with structural lesions resulting from mild traumatic brain injuries constitutional     --over   of GAP43 and neurogranin (NRGN) in CSF from ALzheimer disease patients constitutional     --over   in the AD patients than in cognitively healthy controls

Susceptibility

to schizophrenia

Variant & Polymorphism SNP , other	polymorphism rs12807809 located upstream of the neurogranin (NRGN) gene has been identified as a risk variant for schizophrenia

Candidate gene	may have a role in neurocognitive and behavioral defects in the 11qter deletion disorder DEL11QD (Coldren 2009)
Marker	NRGN and NPTXR concentrations in CSF are promising synaptic dysfunction biomarkers reflecting pathological changes in AD
Therapy target

ANIMAL & CELL MODELS