SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,mitochondria
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,cytosolic
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| intracellular,nucleus
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| text
| in the cerebral cortex, found in the cell bodies of neurons in layers II-VI and in apical and basal dendrites of pyramidal neurons (not found in the dendrites in patients with Alzeihmer disease) |
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was first expressed and secreted by neuro-progenitors while the maximum was reached in mature cortical neurons  |
| basic FUNCTION
| postsynaptic protein kinase substrate that binds calmodulin in the absence of calcium |
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target of thyroid hormone in brain |
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neuronal protein implicated in learning and memory |
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calcium/calmodulin binding protein, and proapoptotic factor |
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with PCP4, small IQ-motif calmodulin (CALM1)-binding proteins originally identified in the central nervous system (Kleerekoper 2009) |
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enhances post-synaptic sensitivity and increases synaptic strength in an activity- and NMDAR-dependent manner (Zhong 2009) |
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acts as a third messenger substrate for protein kinase C-mediated molecular cascades during synaptic development and remodeling |
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is the main postsynaptic protein regulating the availability of calmodulin-Ca(2+) in neurons |
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implicated in spatial learning and hippocampal plasticity |
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increased prefrontal cortex neurogranin enhances plasticity and extinction learning |
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NRGN-mediated enhancement of synaptic strength is due to its ability to target, rather than sequester, CALM1 within dendritic spines |
