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FLASH GENE
Symbol NRGN contributors: SGE/npt - updated : 11-01-2010
HGNC name neurogranin (protein kinase C substrate, RC3)
HGNC id 8000
Location 11q24.2      Physical location : 124.609.828 - 124.617.102
Synonym name
  • calmodulin-binding protein
  • protein kinase C substrate
  • Synonym symbol(s) RC3, hng, Ng
    DNA
    TYPE functioning gene
    STRUCTURE 7.27 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    cytosine-phosphate-guanine/HTF
    text structure
  • thyroid hormone-responsive element in the first intron
  • TATA-less promoter
  • MAPPING cloned Y linked N status provisional
    Physical map
    OR8B5P 11q25 olfactory receptor, family 8, subfamily B, member 5 pseudogene OR8B1P 11q24-q25 olfactory receptor, family 8, subfamily B, member 1 pseudogene OR8C1P 11q24-q25 olfactory receptor, family 8, subfamily C, member 1 pseudogene LOC390271 11 similar to seven transmembrane helix receptor LOC390272 11 similar to seven transmembrane helix receptor LOC283162 11q24.2 similar to Olfactory receptor 8B4 OR8B8 11q24.2 olfactory receptor, family 8, subfamily B, member 8 LOC390273 11 similar to Olfactory receptor 8A1 (OST025) OR8B9P 11q25 olfactory receptor, family 8, subfamily B, member 9 pseudogene LOC390274 11 similar to olfactory receptor MOR161-5 LOC219858 11q24.2 similar to Olfactory receptor 8B12 LOC390275 11 similar to Olfactory receptor 8A1 (OST025) PANX3 11q24.2 pannexin 3 TBRG1 11q24.2 likely ortholog of mouse transforming growth factor beta regulated gene 1 CSE-C 11q24 cytosolic sialic acid 9-O-acetylesterase homolog SPA17 11q24.2 sperm autoantigenic protein 17 NRGN 11q24 neurogranin (protein kinase C substrate, RC3) CTXL 11q24 cortical thymocyte receptor (X. laevis CTX) like ESAM 11q24.2 cortical thymocyte receptor (X. laevis CTX) like FLJ23342 11q24.2 hypothetical protein FLJ23342 RBIG1 11q24.2 retinoblastoma inhibiting gene 1 ROBO4 11q24.2 roundabout homolog 4, magic roundabout (Drosophila) FLJ25530 11q24.2 hypothetical protein FLJ25530 FLJ13215 11q24.2 hypothetical protein FLJ13215 LOC387816 11 similar to hypothetical protein
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 1238 - 78 - -
    4 - 1235 - 78 - -
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineadrenal gland   highly
    Nervousbrainforebraincerebral cortex  
    Reproductivefemale systemovary   
    Visualeye   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one collagen-like domain
  • one IQ domain
  • HOMOLOGY
    interspecies homolog to rattus Nrgn (96.2pc)
    homolog to murine Nrgn (96.2pc)
    Homologene
    FAMILY
  • neurogranin family
  • CATEGORY signaling neurotransmitter
    SUBCELLULAR LOCALIZATION     intracellular
    text in the cerebral cortex, found in the cell bodies of neurons in layers II-VI and in apical and basal dendrites of pyramidal neurons (not found in the dendrites in patients with Alzeihmer disease)
    basic FUNCTION
  • postsynaptic protein kinase substrate that binds calmodulin in the absence of calcium
  • target of thyroid hormone in brain
  • neuronal protein implicated in learning and memory
  • calcium/calmodulin binding protein, and proapoptotic factor
  • with PCP4, small IQ-motif calmodulin (CALM1)-binding proteins originally identified in the central nervous system (Kleerekoper 2009)
  • enhances post-synaptic sensitivity and increases synaptic strength in an activity- and NMDAR-dependent manner (Zhong 2009)
  • acts as a third messenger substrate for protein kinase C-mediated molecular cascades during synaptic development and remodeling
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding calmodulin in the absence of calcium and enhancing synaptic strength (Zhong 2009)
  • cell & other
    REGULATION
    Other expression modulated by thyroid hormones and retinoids (Ruano 2008)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to schizophrenia (Stefansson 2009)
    Variant & Polymorphism other
    Candidate gene may have a role in neurocognitive and behavioral defects in the 11qter deletion disorder DEL11QD (Coldren 2009)
    Marker
    Therapy target
    ANIMAL & CELL MODELS