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FLASH GENE

Symbol

NRGN

contributors: SGE/npt - updated : 11-01-2010

HGNC name	neurogranin (protein kinase C substrate, RC3)
HGNC id	8000

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	11q24.2      Physical location : 124.609.828 - 124.617.102
Synonym name	calmodulin-binding protein
	protein kinase C substrate
Synonym symbol(s)	RC3, hng, Ng

DNA

TYPE	functioning gene
STRUCTURE	7.27 kb     4 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Promoter
	cytosine-phosphate-guanine/HTF
text structure	thyroid hormone-responsive element in the first intron
	TATA-less promoter

MAPPING

cloned

Y

linked

N

status

provisional

Physical map

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001126181 4 - 1238 NP_001119653 - 78 - - NM_006176 4 - 1235 NP_006167 - 78 - -

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine adrenal gland       highly Nervous brain forebrain cerebral cortex     Reproductive female system ovary       Visual eye       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone       Nervous peripherous

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	one collagen-like domain
	one IQ domain

HOMOLOGY

interspecies	homolog to rattus Nrgn (96.2pc)
	homolog to murine Nrgn (96.2pc)

Homologene

FAMILY

neurogranin family

CATEGORY

signaling neurotransmitter

SUBCELLULAR LOCALIZATION	intracellular
text	in the cerebral cortex, found in the cell bodies of neurons in layers II-VI and in apical and basal dendrites of pyramidal neurons (not found in the dendrites in patients with Alzeihmer disease)

basic FUNCTION	postsynaptic protein kinase substrate that binds calmodulin in the absence of calcium
	target of thyroid hormone in brain
	neuronal protein implicated in learning and memory
	calcium/calmodulin binding protein, and proapoptotic factor
	with PCP4, small IQ-motif calmodulin (CALM1)-binding proteins originally identified in the central nervous system (Kleerekoper 2009)
	enhances post-synaptic sensitivity and increases synaptic strength in an activity- and NMDAR-dependent manner (Zhong 2009)
	acts as a third messenger substrate for protein kinase C-mediated molecular cascades during synaptic development and remodeling

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule

protein

binding calmodulin in the absence of calcium and enhancing synaptic strength (Zhong 2009)

cell & other

REGULATION

Other

expression modulated by thyroid hormones and retinoids (Ruano 2008)

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to schizophrenia (Stefansson 2009)

Variant & Polymorphism other

Candidate gene	may have a role in neurocognitive and behavioral defects in the 11qter deletion disorder DEL11QD (Coldren 2009)
Marker
Therapy target

ANIMAL & CELL MODELS