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FLASH GENE

Symbol

ITIH4

contributors: mct/npt - updated : 18-11-2009

HGNC name	inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein)
HGNC id	6169

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_002218 24 - 3283 NP_002209 - 930 - Saguchi (1996) NM_001166449 - - 3193 NP_001159921 - 900 - Saguchi (1996)

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver       highly Lymphoid/Immune thymus

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a VWFA domain
	a proline-rich region

conjugated

GlycoP

HOMOLOGY

Homologene

FAMILY

ITIH family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,nucleus

basic FUNCTION	trypsin inhibitor, may be involved in acute phase reactions
	contributing to extracellular matrix stability by covalent linkage to hyaluronan (Hamm 2008)
	anti-inflammatory protein, extensively proteolytically processed within the proline-rich region (its fragmentation patterns were closely associated with different disease conditions)(Song 2006)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

Other

plasma kallikrein-sensitive

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in multiple solid tumors, including breast, colon and lung cancer (Hamm 2008) constitutional         in acute ischemic stroke (Kashyap 2009)

Susceptibility

Variant & Polymorphism	a C/T single nucleotide polymorphism at IVS17+8 associated with high plasma total cholesterol level

Candidate gene	marker of acute ischemic stroke (Kashyap 2009)
Marker
Therapy target

ANIMAL & CELL MODELS