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FLASH GENE
Symbol ITIH4 contributors: mct/npt - updated : 18-11-2009
HGNC name inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein)
HGNC id 6169
Location 3p21.1      Physical location : 52.847.006 - 52.864.717
Synonym name
  • inter-alpha (protein HC),heavy chain 4
  • ITI heavy chain H4
  • plasma kallikrein sensitive glycoprotein 120
    • Synonym symbol(s) PK-120, H4P, IHRP, PK120, ITIHL1, DKFZp686G21125, GP120
    DNA
    TYPE functioning gene
    STRUCTURE 17.69 kb     24 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    24 - 3283 - 930 - Saguchi (1996)
    - - 3193 - 900 - Saguchi (1996)
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly
    Lymphoid/Immunethymus    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a VWFA domain
  • a proline-rich region
    • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • ITIH family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,nucleus
    basic FUNCTION
  • trypsin inhibitor, may be involved in acute phase reactions
  • contributing to extracellular matrix stability by covalent linkage to hyaluronan (Hamm 2008)
  • anti-inflammatory protein, extensively proteolytically processed within the proline-rich region (its fragmentation patterns were closely associated with different disease conditions)(Song 2006)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other plasma kallikrein-sensitive
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in multiple solid tumors, including breast, colon and lung cancer (Hamm 2008)
    constitutional        
    in acute ischemic stroke (Kashyap 2009)
    Susceptibility
    Variant & Polymorphism a C/T single nucleotide polymorphism at IVS17+8 associated with high plasma total cholesterol level
    Candidate gene marker of acute ischemic stroke (Kashyap 2009)
    Marker
    Therapy target
    ANIMAL & CELL MODELS