| Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
|---|
| tumoral
|
| deletion
|
|
|
|
deleted in large cell neuroendocrine carcinoma |
| tumoral
|
| LOH
|
|
|
|
LOH in ependymomas (in progression) |
| constitutional
| somatic mutation
|
|
|
|
|
mutated in isolated or familial primary hyperparathyrodism |
| tumoral
|
|
|
|
|
|
isolated hyperparathyroid tumor, gastrinoma, insulinoma, bronchial carcinoid |
| tumoral
|
|
|
| loss of function
|
|
in parathyroid, pituitary, islet cells tumor |
| tumoral
|
|
|
| gain of function
|
|
in hepatocellular carcinoma |
| tumoral
|
| deletion
|
|
|
in parathyroid adenomas  |
| tumoral
| somatic mutation
|
|
|
|
|
somatic inactivating mutations n pancreatic neuroendocrine tumors |
| tumoral
|
|
| --over
|
|
|
in hepatocellular carcinoma and correlated with poor prognosis |
| constitutional
|
|
|
| gain of function
|
|
during chronic liver injury plays a crucial role in promoting hepatocarcinogenesis |
