Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol FCGR1A contributors: mct/npt/pgu - updated : 02-04-2010
HGNC name Fc fragment of IgG, high affinity Ia, receptor for (CD64)
HGNC id 3613
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a unique third extracellular domain EC3
  • three immunoglobulin-like C2-type domains
    • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to rattus Rn.16643
    homolog to murine Fcgr1
    homolog to C.elegans B0412.1
    Homologene
    FAMILY
  • immunoglobulin superfamily
  • FCGR1 family
    • CATEGORY antigen , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • type I membrane protein
  • reside within lipid rafts without prior triggering of the receptor
    • basic FUNCTION
  • acting as a receptor for the Fc domain of IgG
  • having a role in immune response
  • play an important role in the internalization of Mycobacterium tuberculosis into macrophages
  • can mediate phagocytosis of opsonized pathogens, but can also effectively capture small immune complexes, and facilitates antigen presentation
  • having the capacity to mediate potent antimalaria immunity
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to the Fc region of Ig G (high affinity)
  • intreacting with LILRB4 (potent inhibitor of FCGR1A-mediated monocyte activation via dephosphorylation of multiple kinases)
  • EPB41L2 binds to a unique motif within FCGR1A cytoplasmic tail
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    on circulating monocytes parallels systemic inflammation and renal disease in SLE patients
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS