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FLASH GENE

Symbol

FCGR1A

contributors: mct/npt/pgu - updated : 02-04-2010

HGNC name	Fc fragment of IgG, high affinity Ia, receptor for (CD64)
HGNC id	3613

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_000566 6 splicing 2268 NP_000557 42.6 374 - 1988 2974947 variant b - splicing 1278 isoform b - 344 - 1988 2974947

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain       moderately Respiratory lung       moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic monocyte Blood/Hematopoietic neutrophil Lymphoid/Immune macrophage

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a unique third extracellular domain EC3
	three immunoglobulin-like C2-type domains

conjugated

GlycoP

HOMOLOGY

interspecies	homolog to rattus Rn.16643
	homolog to murine Fcgr1
	homolog to C.elegans B0412.1

Homologene

FAMILY	immunoglobulin superfamily
	FCGR1 family

CATEGORY

antigen , receptor membrane

SUBCELLULAR LOCALIZATION	plasma membrane
text	type I membrane protein
	reside within lipid rafts without prior triggering of the receptor

basic FUNCTION	acting as a receptor for the Fc domain of IgG
	having a role in immune response
	play an important role in the internalization of Mycobacterium tuberculosis into macrophages
	can mediate phagocytosis of opsonized pathogens, but can also effectively capture small immune complexes, and facilitates antigen presentation
	having the capacity to mediate potent antimalaria immunity

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

immunity/defense

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule

protein	binding to the Fc region of Ig G (high affinity)
	intreacting with LILRB4 (potent inhibitor of FCGR1A-mediated monocyte activation via dephosphorylation of multiple kinases)
	EPB41L2 binds to a unique motif within FCGR1A cytoplasmic tail

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   on circulating monocytes parallels systemic inflammation and renal disease in SLE patients

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS