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FLASH GENE
Symbol FCGR1A contributors: mct/npt/pgu - updated : 02-04-2010
HGNC name Fc fragment of IgG, high affinity Ia, receptor for (CD64)
HGNC id 3613
Location 1q21.2      Physical location : 149.754.249 - 149.764.073
Synonym name
  • cell differentiation antigen CD64,identified by monoclonal antibodies mAb32.3, mAb22
  • CD64 antigen
  • IgG Fc receptor I
    • Synonym symbol(s) CD64, FCGR1, FCRI, IGFR1, CD64A, FLJ18345
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    text member of the FCGR1 cluster
    STRUCTURE 9.83 kb     6 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 splicing 2268 42.6 374 - 1988 2974947
    - splicing 1278 - 344 - 1988 2974947
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   moderately
    Respiratorylung   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmonocyte
    Blood/Hematopoieticneutrophil
    Lymphoid/Immunemacrophage
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a unique third extracellular domain EC3
  • three immunoglobulin-like C2-type domains
    • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to rattus Rn.16643
    homolog to murine Fcgr1
    homolog to C.elegans B0412.1
    Homologene
    FAMILY
  • immunoglobulin superfamily
  • FCGR1 family
    • CATEGORY antigen , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • type I membrane protein
  • reside within lipid rafts without prior triggering of the receptor
    • basic FUNCTION
  • acting as a receptor for the Fc domain of IgG
  • having a role in immune response
  • play an important role in the internalization of Mycobacterium tuberculosis into macrophages
  • can mediate phagocytosis of opsonized pathogens, but can also effectively capture small immune complexes, and facilitates antigen presentation
  • having the capacity to mediate potent antimalaria immunity
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to the Fc region of Ig G (high affinity)
  • intreacting with LILRB4 (potent inhibitor of FCGR1A-mediated monocyte activation via dephosphorylation of multiple kinases)
  • EPB41L2 binds to a unique motif within FCGR1A cytoplasmic tail
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    on circulating monocytes parallels systemic inflammation and renal disease in SLE patients
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS