Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol EFNB3 contributors: npt/shn - updated : 12-01-2012
HGNC name ephrin-B3
HGNC id 3228
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • C terminal region with five conserved tyrosine residues
    • HOMOLOGY
    interspecies ortholog to Efnb3, Mus musculus
    ortholog to Efnb3, Rattus norvegicus
    ortholog to EFNB3, Pan troglodytes
    ortholog to efnb3b, Danio rerio
    Homologene
    FAMILY
  • ephrin family
    • CATEGORY signaling neurotransmitter
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type 1 membrane protein
    basic FUNCTION
  • important in brain development as well as in its maintenance and may play a pivotal role in forebrain function (
  • ligand for eph related kinase, playing a role in local neuronal circuits that control walking
  • involved in short-range contact-mediated axonal guidance
  • essential components of the Reelin receptor/signalling pathway to control neuronal migration during the development of the nervous system (
  • contributes to myelin-derived axonal growth inhibition and limits recovery from adult CNS trauma
  • contributes to myelin-dependent failure of axonal regeneration
  • is a physiologically important myelin-associated inhibitor of axonal growth in the adult central nervous system
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • EPH receptor B3, EPHB3 (
  • EPH receptor A4, EPHA4 (
  • EPH receptor A4, EPHB4 (
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in stage neuroblastoma and NTRK1 high expression
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Efnb3(-/-) knockout show neuronal migration defects that recapitulate the ones observed in the neocortex, hippocampus and cerebellum of the reeler mouse (
  • triple ephrin B1, B2, B3 knockouts knockout show neuronal migration defects that recapitulate the ones observed in the neocortex, hippocampus and cerebellum of the reeler mouse (