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FLASH GENE
Symbol EFNB3 contributors: npt/shn - updated : 12-01-2012
HGNC name ephrin-B3
HGNC id 3228
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   lowly Homo sapiens
Nervousbraindiencephalonthalamus lowly Homo sapiens
 brainmidbrainsubstantia nigra moderately Homo sapiens
 brainlimbic systemhippocampus highly Homo sapiens
 brainbasal nucleicorpus callosum lowly Homo sapiens
 braindiencephalonamygdala highly Homo sapiens
 brainbasal nucleicaudate nucleus highly Homo sapiens
 brainbasal nucleiputamen highly Homo sapiens
 brainforebraincerebral lobetemporal lobehighly Homo sapiens
 brainforebraincerebral lobefrontal lobehighly Homo sapiens
 brainforebraincerebral lobeoccipital lobehighly Homo sapiens
 brainhindbrainmedulla oblongata lowly Homo sapiens
 brainforebraincerebral cortex highly Homo sapiens
 brainhindbraincerebellum moderately Homo sapiens
 brain   highly Homo sapiens
 braindiencephalonthalamusnucleimoderately Homo sapiens
 spinal cord   lowly Homo sapiens
Respiratorylung   lowly Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousoligodendrocyte Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal, pregnancy
Text heart, brain, lung and kidney (
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • C terminal region with five conserved tyrosine residues
  • HOMOLOGY
    interspecies ortholog to Efnb3, Mus musculus
    ortholog to Efnb3, Rattus norvegicus
    ortholog to EFNB3, Pan troglodytes
    ortholog to efnb3b, Danio rerio
    Homologene
    FAMILY
  • ephrin family
  • CATEGORY signaling neurotransmitter
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type 1 membrane protein
    basic FUNCTION
  • important in brain development as well as in its maintenance and may play a pivotal role in forebrain function (
  • ligand for eph related kinase, playing a role in local neuronal circuits that control walking
  • involved in short-range contact-mediated axonal guidance
  • essential components of the Reelin receptor/signalling pathway to control neuronal migration during the development of the nervous system (
  • contributes to myelin-derived axonal growth inhibition and limits recovery from adult CNS trauma
  • contributes to myelin-dependent failure of axonal regeneration
  • is a physiologically important myelin-associated inhibitor of axonal growth in the adult central nervous system
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • EPH receptor B3, EPHB3 (
  • EPH receptor A4, EPHA4 (
  • EPH receptor A4, EPHB4 (
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in stage neuroblastoma and NTRK1 high expression
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Efnb3(-/-) knockout show neuronal migration defects that recapitulate the ones observed in the neocortex, hippocampus and cerebellum of the reeler mouse (
  • triple ephrin B1, B2, B3 knockouts knockout show neuronal migration defects that recapitulate the ones observed in the neocortex, hippocampus and cerebellum of the reeler mouse (