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FLASH GENE

Symbol

EFNB3

contributors: npt/shn - updated : 12-01-2012

HGNC name	ephrin-B3
HGNC id	3228

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	6.17 kb     5 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

Map	pter - D17S960 - D17S960 - EFNB3 - D17S1353 - D17S1796 - cen

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001406 5 - 3236 NP_001397 33.3 340 - -

EXPRESSION

Type	restricted

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       lowly Homo sapiens Nervous brain diencephalon thalamus   lowly Homo sapiens   brain midbrain substantia nigra   moderately Homo sapiens   brain limbic system hippocampus   highly Homo sapiens   brain basal nuclei corpus callosum   lowly Homo sapiens   brain diencephalon amygdala   highly Homo sapiens   brain basal nuclei caudate nucleus   highly Homo sapiens   brain basal nuclei putamen   highly Homo sapiens   brain forebrain cerebral lobe temporal lobe highly Homo sapiens   brain forebrain cerebral lobe frontal lobe highly Homo sapiens   brain forebrain cerebral lobe occipital lobe highly Homo sapiens   brain hindbrain medulla oblongata   lowly Homo sapiens   brain forebrain cerebral cortex   highly Homo sapiens   brain hindbrain cerebellum   moderately Homo sapiens   brain       highly Homo sapiens   brain diencephalon thalamus nuclei moderately Homo sapiens   spinal cord       lowly Homo sapiens Respiratory lung       lowly Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Nervous oligodendrocyte Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal, pregnancy

Text	heart, brain, lung and kidney (

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

C terminal region with five conserved tyrosine residues

HOMOLOGY

interspecies	ortholog to Efnb3, Mus musculus
	ortholog to Efnb3, Rattus norvegicus
	ortholog to EFNB3, Pan troglodytes
	ortholog to efnb3b, Danio rerio

Homologene

FAMILY

ephrin family

CATEGORY

signaling neurotransmitter

SUBCELLULAR LOCALIZATION	plasma membrane
text	type 1 membrane protein

basic FUNCTION	important in brain development as well as in its maintenance and may play a pivotal role in forebrain function (
	ligand for eph related kinase, playing a role in local neuronal circuits that control walking
	involved in short-range contact-mediated axonal guidance
	essential components of the Reelin receptor/signalling pathway to control neuronal migration during the development of the nervous system (
	contributes to myelin-derived axonal growth inhibition and limits recovery from adult CNS trauma
	contributes to myelin-dependent failure of axonal regeneration
	is a physiologically important myelin-associated inhibitor of axonal growth in the adult central nervous system

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	EPH receptor B3, EPHB3 (
	EPH receptor A4, EPHA4 (
	EPH receptor A4, EPHB4 (

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in stage neuroblastoma and NTRK1 high expression

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

	Efnb3(-/-) knockout show neuronal migration defects that recapitulate the ones observed in the neocortex, hippocampus and cerebellum of the reeler mouse (
	triple ephrin B1, B2, B3 knockouts knockout show neuronal migration defects that recapitulate the ones observed in the neocortex, hippocampus and cerebellum of the reeler mouse (