Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Orphanet	Ensembl
	HGNC	UniGene	Nucleotide	OMIM		UCSC

Home Page

FLASH GENE

Symbol

TWIST2

contributors: mct - updated : 21-08-2015

HGNC name	twist homolog 2 (Drosophila)
HGNC id	20670

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

FFDD3 , FFDD2 , BBRSAY , ABPMS

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional       gain of function increases the resistance to galectin-1-mediated-apoptosis, which may have significant implications for the progression of some T-cells into tumors such as Sezary cells tumoral     --over   may contribute to breast cancer progression by activating the EMT programme and enhancing the self-renewal of cancer stem-like cells (

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer digestive liver identification of the TWIST2-CD24 signaling pathway provides a potential therapeutic approach to target cancer stem cells in HCCs

ANIMAL & CELL MODELS

Adult Twist2-null mice display enophthalmia and blepharophimosis