Symbol
| TWIST2
| contributors: mct - updated : 21-08-2015
|
HGNC name
| twist homolog 2 (Drosophila)
|
HGNC id
| 20670
|
Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
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constitutional
|  
|  
|  
| gain of function
|
increases the resistance to galectin-1-mediated-apoptosis, which may have significant implications for the progression of some T-cells into tumors such as Sezary cells ![](pubmed.jpg) | tumoral
|  
|  
| --over
|  
|
may contribute to breast cancer progression by activating the EMT programme and enhancing the self-renewal of cancer stem-like cells ( | |
Variant & Polymorphism
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| |
Candidate gene
Marker
Therapy target
|
System | Type | Disorder | Pubmed |
cancer | digestive | liver | ![](pubmed.jpg) |
identification of the TWIST2-CD24 signaling pathway provides a potential therapeutic approach to target cancer stem cells in HCCs |
| | | |
| Adult Twist2-null mice display enophthalmia and blepharophimosis ![](pubmed.jpg) |