basic FUNCTION
| maintaining cells in an osteoprogenitor or preosteoblast-like state and preventing premature or ectopic osteoblast differentiation |
|
role of TWIST2 in silencing TP53 function in several malignancies |
|
repressing MYOD1 transactivation via the HLH domain, MEF2 interaction and chromatin deacetylation |
|
key negative regulator of myeloid lineage development |
|
critical role in regulating the development of myeloid lineages, as well as the function and inflammatory responses of mature myeloid cells |
|
potential mediator of mesenchymal stromal/stem cells self-renewal and lineage commitment in postnatal skeletal tissues by exerting their effects on genes involved in the early stages of bone development |
|
regulates CD7 expression and galectin-1-induced apoptosis in mature T-cells |
|
critical for normal mesenchymal proliferation and differentiation |
|
potentially required for normal corneal keratocyte proliferation and eyelid morphogenesis |
|
potential involvement in the regulation of osteoblastogenesis by HB-EGF-EGFR signaling |
|
regulates early limb morphogenesis through a role in terminating the SHH/GREM1/FGF autoregulatory loop |
|
TWIST1 and TWIST2 regulate osteocalcin transcription in part through the interaction of the C-terminal "box" domain in these factors and RUNX2 |
|
is a key regulator of survival, invasion and anchorage-independent growth in the aneuploid cells |
|
augments liver cancer stem-like cell self-renewal in a CD24-dependent manner |
|
TWIST1 and TWIST2 regulate glycogen storage and inflammatory genes in skeletal muscle |
|
basic helix-loop-helix transcription factor that regulates the development of mesenchymal tissues |