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FLASH GENE
Symbol SFRP4 contributors: mct/npt - updated : 02-02-2009
HGNC name secreted frizzled-related protein 4
HGNC id 10778
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a frizzled-like cysteine-rich domain
  • a conserved hydrophilic carboxyterminal domain
  • netrin C terminal domain
    • HOMOLOGY
    interspecies homolog to Drosophila frizzled polarity
    homolog to murine Sfrp 4
    Homologene
    FAMILY
  • secreted frizzled-related protein (SFRP) family
    • CATEGORY signaling
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • playing a potential role in the pathogenesis of ADPKD (Romaker 2009)
  • likely involved in WNT binding, and acting as soluble modulators of Wnt signaling
  • promotes epidermal differentiation (Maganga 2008)
  • reduces sodium-phosphate co-transporter abundance and activity in proximal tubule cells (Berndt 2006)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by increased gradually during adipogeneis via inhibition of Wnt signaling
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   LOH    
    in colorectal tumor
    tumoral     --over  
    associated with a good prognosis in localized androgen-dependent prostate cancer
    tumoral     --over  
    in colorectal carcinoma
    constitutional     --over  
    in failing ventricles and ventricular myocardium
    constitutional     --over  
    in ADPKD
    Susceptibility
    Variant & Polymorphism
    Candidate gene DNA methylation markers of Gastric cancer (GC), which may serve as useful markers that may identify a distinct subset of GC (Kang 2008)
    Marker
    Therapy target potential therapeutic strategies to modulate Wnt signaling by SFRP4 will be relevant to both localized androgen-dependent prostate cancer and advanced metastatic disease
    ANIMAL & CELL MODELS