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FLASH GENE

Symbol

SFRP4

contributors: mct/npt - updated : 02-02-2009

HGNC name	secreted frizzled-related protein 4
HGNC id	10778

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	10.83 kb     6 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

tentative : very preliminary evidence

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 6 - 2974 isoform 1 - 346 - Horvath (2007)

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Skin/Tegument skin

cells

System Cell Pubmed Species Stage Rna symbol Skin/Tegument keratinocyte

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a frizzled-like cysteine-rich domain
	a conserved hydrophilic carboxyterminal domain
	netrin C terminal domain

HOMOLOGY

interspecies	homolog to Drosophila frizzled polarity
	homolog to murine Sfrp 4

Homologene

FAMILY

secreted frizzled-related protein (SFRP) family

CATEGORY

signaling

SUBCELLULAR LOCALIZATION

extracellular

basic FUNCTION	playing a potential role in the pathogenesis of ADPKD (Romaker 2009)
	likely involved in WNT binding, and acting as soluble modulators of Wnt signaling
	promotes epidermal differentiation (Maganga 2008)
	reduces sodium-phosphate co-transporter abundance and activity in proximal tubule cells (Berndt 2006)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

activated by

increased gradually during adipogeneis via inhibition of Wnt signaling

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   LOH     in colorectal tumor tumoral     --over   associated with a good prognosis in localized androgen-dependent prostate cancer tumoral     --over   in colorectal carcinoma constitutional     --over   in failing ventricles and ventricular myocardium constitutional     --over   in ADPKD

Susceptibility

Variant & Polymorphism

Candidate gene	DNA methylation markers of Gastric cancer (GC), which may serve as useful markers that may identify a distinct subset of GC (Kang 2008)
Marker
Therapy target	potential therapeutic strategies to modulate Wnt signaling by SFRP4 will be relevant to both localized androgen-dependent prostate cancer and advanced metastatic disease

ANIMAL & CELL MODELS