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	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

FRZB

contributors: MCT - updated : 14-12-2018

HGNC name	frizzled-related protein
HGNC id	3959

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   translocation     osteogenic sarcoma (OGS) induced by silent expression of FRZB silent mechanism not yet known constitutional     --over   in failing ventricles and ventricular myocardium tumoral     --low   in malignant melanoma tumors as compared to normal/benign tissue constitutional     --low   of FRZB may contribute to the pathogenesis of IUGR placental dysfunction, whereas the loss of the protein may be involved in the development of human trophoblastic tumors

Susceptibility

to hip osteoarthritis in the female to atrioventricular septal defects

Variant & Polymorphism	Arg200Trp and Arg324Gly increasing the risk factor for primary hip osteoarthritis in the female

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer     usefulness of FRZB in modulating MET signaling as a new treatment strategy for soft tissue sarcomas

ANIMAL & CELL MODELS