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FLASH GENE

Symbol

CD6

contributors: mct - updated : 24-08-2016

HGNC name	CD6 antigen
HGNC id	1691

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	48.74 kb     13 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

provisional

Map	cen - MS4A2 - D11S461 - CD6 - D11S765 - CD5 - PGA@ - DDB1 - D11S678 - D11S2319E - D11S2224E - SYT7 - D11S734 - FEN1 - D11S699 - D11S471 - FTH1 - SCGB1A1 - AHNAK - qter
Authors	Bowen (97),Cooper (98)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001254751 11 - 3074 NP_001241680 - 592 - 2013 23711376 NM_001254750 11 - 3101 NP_001241679 - 601 - 2013 23711376 NM_006725 13 - 3309 NP_006716 - 668 - 2013 23711376 CD6 delta d3 - splicing - - - - 2014 24890719 alternatively spliced isoform that lacks the ligand-binding domain and thus no longer localizes at the immunological synapse

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen         Nervous nerve spinal nerve sciatic     Reproductive male system prostate       Respiratory lung         Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone subchondral     Lymphoid         Nervous peripherous

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic leukocyte Homo sapiens Blood/Hematopoietic thymocyte Lymphoid/Immune B cell Homo sapiens Lymphoid/Immune T cell Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	transmembrane protein (TM1) with three extracellular scavenger receptor cysteine-rich domains (SRCR,group B)
	cytoplasmic tail lacks intrinsic catalytic activity but presents several consensus motifs for phosphorylation

conjugated

GlycoP

HOMOLOGY

interspecies

homolog to murine Cd6

Homologene

FAMILY

CATEGORY

antigen

SUBCELLULAR LOCALIZATION	plasma membrane
text	type1 membrane protein

basic FUNCTION	involved in cell adhesion
	is likely a signaling attenuator whose expression alone, i.e. in the absence of ligand engagement, is sufficient to restrain signaling in T cells
	modulator of cellular responses and implicated in several autoimmune diseases such as multiple sclerosis, rheumatoid arthritis, and psoriasis
	role of CD6 in autoimmunity
	lymphocyte surface receptor putatively involved in T cell development and activation
	modulates the threshold for thymocyte selection and the generation and/or function of several peripheral T cell subpopulations, including T reg cells

CELLULAR PROCESS	cell life

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	direct interaction between LCP2 and CD6 was shown by binding both to a phosphorylated peptide
	contribute to DC-T-cell adhesion, stabilize DC-T-cell contacts and form a mechanical link between CD6 and the actin cortex to strengthen cell adhesion at the immunological synapse
	upon T cell activation, SRSF1 becomes limiting, and its function in CD6 exon 5 splicing is countered by an increase in CD6 transcription, dependent on chromatin acetylation
	interaction of LGALS1 and LGALS3 with CD6 and CD166/ALCAM might modulate some relevant aspects of T cell physiology
	interaction between CD6 and ALCAM regulating T-cell activation
	facilitates adhesion between T cells and antigen-presenting cells through its interaction with ALCAM, and physically associates with the T cell receptor (TCR) at the center of the immunological synapse
	novel interactions between the SH2D2A SH2 domain and CD6 phosphotyrosine (pTyr)629 and linker of activated T cells (LAT) pTyr171 , pTyr191 and pTyr226

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to multiple sclerosis

Variant & Polymorphism SNP	rs17824933 increasing susceptibility to multiple sclerosis, and is associated with decreased expression of full-length CD6 in CD4(+) and CD8(+) T cells

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS