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FLASH GENE
Symbol RPL37 contributors: mct - updated : 02-04-2014
HGNC name ribosomal protein L37
HGNC id 10347
Location 5p13.1      Physical location : 40.831.429 - 40.835.387
DNA
TYPE functioning gene
STRUCTURE 3.96 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned   linked   status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 1586 - 97 - 2013 23874713
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
cell lineage
cell lines Hela cell
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
multiple serine/threonine phosphorylation sites and a zinc finger domain
HOMOLOGY
Homologene
FAMILY
CATEGORY RNA associated
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic,ribosome
basic FUNCTION
  • 60S ribosomal protein L37
  • DNA damage-induced proteasomal degradation of RPL37 constitutes a mechanistic link between DNA damage and the ribosomal stress pathway, and is a relevant contributing signaling pathway for the activation of TP53 in response to DNA damage
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component constituent of ribosome,large subunit
    INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • CSNK2A1 is responsible for phosphorylation of SSB protein serine-366 and can modulate RPL37 5prime-terminal oligopyrimidine mRNA metabolism
  • RPL37, RPS15 and RPS20 regulate the MDM2-TP53-MDM4 network
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS