Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

DUSP4

contributors: mct/npt/pgu - updated : 31-08-2018

HGNC name	dual specificity phosphatase 4
HGNC id	3070

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in senescent fibroblasts, compared to their young counterparts tumoral somatic mutation     gain of function activating KRAS mutations is significantly correlated to an upregulation of 13 genes among them DUSP4, a MAP-kinase phosphatase, and SMYD3 in colorectal cancer tumoral     --low   through activation of the MAPK signaling pathway is responsible for progression of Colorectal cancer tumoral   deletion     in approximately 50 p100 of breast cancers

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	low DUSP4 expression levels predict recurrence and mortality in Triple-negative breast cancer (TNBC) patients independently from known clinical and molecular predictors
Therapy target
	System Type Disorder Pubmed respiratory lung   might be a novel therapeutic target in severe asthma

ANIMAL & CELL MODELS