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FLASH GENE
Symbol CEACAM8 contributors: mct - updated : 03-05-2011
HGNC name carcinoembryonic antigen-related cell adhesion molecule 8
HGNC id 1820
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an immunoglobulin-like V-type domain
  • two immunoglobulin-like C2-type domains
    • conjugated GlycoP
    HOMOLOGY
    intraspecies homolog to carcinoembryonic antigen
    Homologene
    FAMILY
  • immunoglobulin superfamily
  • CEA subfamily
    • CATEGORY adhesion , antigen
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    text
  • attached to the membrane by a GPI-anchor
  • localized in lipid rafts
    • basic FUNCTION
  • acting as a tumor antigen
  • involved in regulating adhesion and activation of eosinophils, possibly through their localization in lipid rafts and interaction with other cell surface molecules, such as CD11b
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in primary myelofibrosis (
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS