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FLASH GENE
Symbol CEACAM8 contributors: mct - updated : 03-05-2011
HGNC name carcinoembryonic antigen-related cell adhesion molecule 8
HGNC id 1820
Location 19q13.2      Physical location : 43.084.394 - 43.099.082
Synonym name carcinoembryonic antigen gene family, 6
Synonym symbol(s) CGM6, CD67, CD66b, NCA-95
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
STRUCTURE 14.69 kb     6 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Map see CEA@ ,PSG@
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 2333 - 349 - 2007 18056392
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Respiratorylung   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticeosinophil Homo sapiens
cell lineage
cell lines leukocytes of chronic myeloid leukemia
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an immunoglobulin-like V-type domain
  • two immunoglobulin-like C2-type domains
  • conjugated GlycoP
    HOMOLOGY
    intraspecies homolog to carcinoembryonic antigen
    Homologene
    FAMILY
  • immunoglobulin superfamily
  • CEA subfamily
  • CATEGORY adhesion , antigen
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    text
  • attached to the membrane by a GPI-anchor
  • localized in lipid rafts
  • basic FUNCTION
  • acting as a tumor antigen
  • involved in regulating adhesion and activation of eosinophils, possibly through their localization in lipid rafts and interaction with other cell surface molecules, such as CD11b
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in primary myelofibrosis (
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS