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FLASH GENE

Symbol

KLRB1

contributors: mct - updated : 04-04-2014

HGNC name	killer cell lectin-like receptor subfamily B, member 1
HGNC id	6373

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	an extracytoplasmic carbohydrate recognition domain homologous with C type lectin superfamily member, like Ly-49
	one C-type lectin-like domain in the extracellular region responsible for the ligand recognition, that bound directly to CLEC2D

mono polymer

homomer , dimer

HOMOLOGY

Homologene

FAMILY	natural killer cell lectin-like receptor family
	subfamily B

CATEGORY

antigen , receptor

SUBCELLULAR LOCALIZATION	plasma membrane
text	type II integral membrane protein

basic FUNCTION	triggering cellular activation of NK cells and target lysis
	its signaling in NK cells involves the activation of acid sphingomyelinase
	role for CLEC2D/KLRB1 in modulating immune responses to pathogens

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

KLRB1 and ENTPD1 have direct interactions that are further linked with acid sphingomyelinase (ASM)

cell & other

REGULATION

induced by

RORC (marker of all IL17-producing T-cell subsets and is induced by RORC)

Other

regulated by IL2 and IL12

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   in multiple sclerosis

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS