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FLASH GENE

Symbol

EPHB3

contributors: mct - updated : 25-02-2016

HGNC name	EPH receptor B3
HGNC id	3394

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	3q27.1      Physical location : 184.279.586 - 184.300.195
Synonym name	EPH-related tyrosine kinase receptor B3
	human embryonic kinase 2
	EPH-like tyrosine kinase-2
	ephrin receptor EphB3
Synonym symbol(s)	ETK2, HEK2, TYRO6
EC.number	2.7.10.1

DNA

TYPE	functioning gene
STRUCTURE	20.61 kb     16 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_004443 16 - 4234 NP_004434 - 998 - 2004 15047175

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine colon   highly   pharynx       highly   salivary gland       highly Lymphoid/Immune thymus         Homo sapiens Nervous brain basal nuclei striatum     Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Nervous peripherous

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune epithelial cell Homo sapiens Nervous neuron Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

Text	expressed in ventral midbrain during development

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a vestigial Ig-l domain
	a single cysteine rich region and two FNIII domains in the extracellular region
	a SAM (sterile alpha motif) domain

HOMOLOGY

Homologene

FAMILY	protein kinase superfamily
	Tyr protein kinase family
	ephrin receptor

CATEGORY

enzyme , receptor

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane

basic FUNCTION	receptor tyrosine kinase, involved in short-range contact-mediated exonal guidance
	catalytic activity of EPHB3 is required for inhibition of integrin-mediated cell adhesion
	involved in neural and vascular patterning
	multi-functional factor that regulates cell apoptosis and augments T-cell signaling
	could mediate axon pruning and control axon pathfinding
	potentially played an important role in midbrain dopaminergic neurons
	directly involved in the specificity of mesostriatal projection
	axon guide molecule, probably participated in mesostriatal axonal growth to target region
	limits the expansion of neural progenitor cells in the subventricular zone by regulating TP53 during homeostasis and following traumatic brain injury

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	receptor for members of the ephrin-b family, binds to ephrin-b1 and -b2 (EPHB1, EPHB2)
	EPHB3-ephrin-B interaction promotes MET (mesenchymal-to-epithelial transition) by re-establishing epithelial cell-cell junctions and such an MET-promoting effect contributes to EPHB3-mediated tumor suppression
	interact with E-cadherin and with the metalloproteinase ADAM10 at sites of adhesion and their activation induces shedding of CDH1 by ADAM10 at interfaces with EPHB1-expressing cells
	HUWE1 regulates the intestinal stem cell niche via the WNT pathway and targets EPHB3 for proteasomal and lysosomal degradation

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   in proliferating hemangiomas tumoral     --over   in non-small-cell lung cancer

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer lung   potential therapeutic target innon-small-cell lung cancer

ANIMAL & CELL MODELS