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FLASH GENE
Symbol CEACAM7 contributors: mct - updated : 23-09-2020
HGNC name carcinoembryonic antigen-related cell adhesion molecule 7
HGNC id 1819
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal dimerization domain
  • an immunoglobulin-like V-type domain
  • an immunoglobulin-like C2-type domain
    • conjugated GlycoP
    HOMOLOGY
    intraspecies homolog to carcinoembryonic antigen
    Homologene
    FAMILY
  • immunoglobulin superfamily
  • CEA subfamily
    • CATEGORY adhesion , antigen , tumor suppressor
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    text attached to the membrane by a GPI-anchor
    basic FUNCTION
  • CEACAM6 and CEACAM7 expression correlated with apoptosis at the table region of the normal colon
  • cellular adhesion protein that is expressed on the surface of colon and rectum epithelial cells and is downregulated in colorectal cancers
  • achieves cell adhesion through dimerization of the N-terminal IgV domain
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • IFNG has two important effects on the expression levels of the CEA family molecules in colon epithelial cells: direct upregulation of CEACAM1 and promotion of cell differentiation resulting in increased expression of CEA and CEACAM6 and decreased expression of CEACAM7
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    associated with unfavorable prognosis in Colorectal cancer
    tumoral     --low  
    relatively decreased in rctal tumors that developed recurrence compared with nonrecurrence, significantly for stage II patients
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • CEACAM7, SLC4A4, GCG and CLCA1 may be prognostic markers or therapeutic targets of Colorectal cancer
  • potential tumor marker to define a subset of patients who benefit most from adjuvant therapy
    • Therapy target
    ANIMAL & CELL MODELS